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KMID : 0604520050310020153
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Journal of the Society of Cosmetic Scientists of Korea
2005 Volume.31 No. 2 p.153 ~ p.159
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The Study on the Whitening Effect of Ephedra sinica Extract
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Yoo Young-Keun
Joung Min-Seok
Choi Jong-Wan
Kim Joong-Hoe
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Abstract
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In this study, we investigated the application of an extract from Ephedra sinica which has been composed of traditional Korean medicine as a whitening ingredient. The extract of Ephedra sinica which was obtained from the mixture of methanol and water (1:1) the inhibitory effect of tyrosinase. Then, Ephedra sinica was extracted by two different solvents. One was water and the other was methylene chloride. Only, the water extract of Ephedra sinica showed the inhibitory effort of tyrosinase; the anti-tyrosinase activity with 0.2% of the water extract was 60.6%. But the extract of Ephedra sinica in methylene chloride fraction showed little inhibitory effect on tyrosinase. The inhibitory effect of the concentrated water extract of Ephedra sinica was tested on L-DOPA auto-oxidation and melanin synthesis in B-16 melanoma. In L-DOPA auto-oxidation, 0.5% of the concentrated water extract showed 87% of inhibition of L-DOPA auto-oxidation and the 0.75% concentrated Ephedra sinica extract in wafer fraction inhibited 98.8% of that. In melanin synthesis of B-16 melanoma, the concentrated water effect of Ephedra sinica inhibited 70.2% or 79.9% of inhibitory effect on that at the concentration of 0.05% or 0.075%, respectively. For verifying the skin whitening effect of the concentrated water extract of Ephedra sinica in vivo, we performed the clinical test of that. The research showed the significant skin whitening effect of a cream containing 0.5% Ephedra sinica extract and the statistical analysis showed a significant difference (p < 0.05) between sample (containing 0.5% Ephedra sinica extract) and placebo after 10 weeks.
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KEYWORD
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Ephedra sinica, skin whirening effect, L-DOPA auto-oxidation, traditional Korean medicine, water extract
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